Myelosuppression affects which structure

Severe myelosuppression, called myeloablation, can be fatal. Myelosuppression can decrease some or all of these. A decrease in all three types of blood cells is referred to as pancytopenia.

This condition is life-threatening. It can cause an oxygen shortage and other immune issues. Symptoms of myelosuppression depend on the type of blood cell affected and the severity of your condition.

In more common cases of myelosuppression, you may experience:. If you develop anemia from low red blood cell production, you may experience:. If you develop thrombocytopenia from a decrease in platelet count, you may experience symptoms including:. Myelosuppression is a common side effect of chemotherapy.

While this procedure is meant to destroy cancer cells, it can also affect your bone marrow and destroy your healthy blood cells. In mild cases of myelosuppression, treatment is not necessary. Blood count production will return to normal in a matter of weeks. If your myelosuppression causes harmful side effects and affects your quality of life, chemotherapy may be stalled or stopped altogether to increase blood cell production. If you begin to experience myelosuppression from bone marrow failure, doctors may recommend a transplant or transfusion to replenish blood cells.

An alternative to transfusions is growth factor injections. These injections are natural chemicals that help boost bone marrow performance. They can be targeted to increase specific blood cell production. If left untreated, or in more severe cases, myelosuppression can be fatal. Before deciding on a chemotherapy treatment, be sure to discuss the risks of myelosuppression with your doctor.

If you begin to experience harmful side effects from myelosuppression as a result of your cancer treatment, seek medical attention.

Blood cell disorders impair the formation and function of red blood cells, white blood cells, or platelets. Radiation and chemotherapy are treatments for cancer.

Lu et al. In conclusion, our findings suggest that the conbination therapy of curcumin and carboplatin improves myelosuppression induced by carboplatin, increases the survival rate of tumor-bearing mice and provides novel mechanistic insight to explain the benefits of curcumin with respect to carboplatin-induced side effects. As curcumin is a safe food supplement, our study provides evidence that curcumin can be further developed as a potential combination agent with carboplatin in the future.

Louis, MO. All methods were performed in accordance with the relevant guidelines and regulations. All animal experiments were carried out in accordance with the protocol approved by Nanjing University Animal Care and Use Committee Wash the femur with PBS and then cut both ends of the femur. Use PBS to swash the bone marrow into an Eppendorf tube. Wash the marrow with PBS twice. Animal blood was collected by eyeball removal in the presence of anticoagulant EDTA.

Hematological parameters including white blood cells, red blood cells, and platelet counts were measured by haematology analyser Sysmex XTiv, Sysmex, Japan. The cells were washed twice with PBS after removal of the media. Protein concentration of the lysates was determined with BCA protein quantitation kit. The labeled proteins were then acetone-precipitated and air-dried.

Coomassie Brilliant Blue Staining was applied to visualize the total proteins. ECL luminescence was applied to visualized the modified proteins. After on-beads digestion, the target proteins were identified with iTRAQ according to the previously published method GraphPad prism 5.

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Tumor-derived VEGF modulates hematopoiesis. Cell 1 , 9 Download references. You can also search for this author in PubMed Google Scholar. Correspondence to Zichun Hua. Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Reprints and Permissions. Chen, X. Curcumin activates DNA repair pathway in bone marrow to improve carboplatin-induced myelosuppression.

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